2,5-Oxyarylation of Furans: Synthesis of Spiroacetals via Palladium-Catalyzed Aerobic Oxidative Coupling of Boronic Acids with α-Hydroxyalkylfurans - Organic Letters (ACS Publications)

2,5-Oxyarylation of Furans: Synthesis of Spiroacetals via Palladium-Catalyzed Aerobic Oxidative Coupling of Boronic Acids with α-Hydroxyalkylfurans - Organic Letters (ACS Publications)

Jiuyi Li, Hui Peng, Furong Wang, Xiujun Wang, Huanfeng Jiang, and Biaolin Yin^*

School of Chemistry and Chemical
Engineering, South China University of Technology, Guangzhou 510641, China

Org. Lett., Article ASAP

DOI: 10.1021/acs.orglett.6b01472

Publication Date (Web): June 16, 2016

Copyright © 2016 American Chemical Society

*E-mail: blyin@scut.edu.cn.

Abstract

A
protocol for the 2,5-oxyarylation of furan rings via Pd-catalyzed
aerobic oxidative coupling of boronic acids with α-hydroxyalkylfurans is
reported. This protocol provides rapid, green access to diverse
biologically interesting and synthetically useful unsaturated
spiroacetals from sustainable furan derivatives.