Institut
für Organische
und Biomolekulare Chemie, Georg-August-Universität, Tammannstraße 2, 37077 Göttingen, Germany
für Organische
und Biomolekulare Chemie, Georg-August-Universität, Tammannstraße 2, 37077 Göttingen, Germany
ACS Catal., 2016, 6, pp 3743–3752
DOI: 10.1021/acscatal.6b00993
Publication Date (Web): April 27, 2016
Copyright © 2016 American Chemical Society
Abstract
Manganese
is found in the active center of numerous enzymes that operate by an
outer-sphere homolytic C–H cleavage. Thus, a plethora of bioinspired
radical-based C–H functionalizations by manganese catalysis have been
devised during the past decades. In contrast, organometallic C–H
activation by means of manganese catalysis has emerged only recently as
an increasingly viable tool in organic synthesis. These
manganese(I)-catalyzed processes enabled a variety of C–H
functionalizations with ample scope, which very recently set the stage
for substitutive C–H functionalizations. The versatile manganese
catalysis largely operates by an isohypsic, thus redox-neutral, mode of
action through chelation assistance, and provided step-economical access
to structurally divers compounds of relevance to inter alia bioorganic, agrochemical, and medicinal chemistry as well as the material sciences.
is found in the active center of numerous enzymes that operate by an
outer-sphere homolytic C–H cleavage. Thus, a plethora of bioinspired
radical-based C–H functionalizations by manganese catalysis have been
devised during the past decades. In contrast, organometallic C–H
activation by means of manganese catalysis has emerged only recently as
an increasingly viable tool in organic synthesis. These
manganese(I)-catalyzed processes enabled a variety of C–H
functionalizations with ample scope, which very recently set the stage
for substitutive C–H functionalizations. The versatile manganese
catalysis largely operates by an isohypsic, thus redox-neutral, mode of
action through chelation assistance, and provided step-economical access
to structurally divers compounds of relevance to inter alia bioorganic, agrochemical, and medicinal chemistry as well as the material sciences.
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